Charmaine has extensive experience in the development of small molecule NCEs that cover a range of therapeutic areas. She has, within the contract research and development arena, worked on behalf of start-up and major pharmaceutical companies to enable a number of products to enter clinical trials as parenterals, topicals and solid oral dosage forms. Charmaine has held Director level positions responsible for preclinical and pharmaceutical development within OSI Pharmaceuticals and was instrumental in introducing high throughput screening methods to assist in lead candidate selection of therapeutics and cosmeceuticals.

From 2002 she focussed on establishing the supply chain for OSI’s “flagship” product, Tarceva, to support Phase III clinical development and commercial launch in the US taking responsibility for global outsourcing of all drug substance and drug product manufacturing. 

Charmaine led all Tarceva CMC-related activities in the US including provision of the CMC module of the NDA that gained US approval. Building on this multi-disciplinary experience Charmaine has now co-founded PharMomentum Ltd as a “hands on”, problem solving consultancy group.